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Posted by on Jan 28, 2013 in Breaking News, Medical Research Data | 0 comments

Mayo Clinic and Big Data

Medical Big Data and Collaboration News Releases:

Resource: News Release:

Optum, Mayo Clinic Partner to Launch Optum Labs: An Open, Collaborative Research and Innovation Facility Focused on Better Care for Patients

Other participants from health care, science and academia expected to share insights and pursue solutions that improve health outcomes for people

Optum and Mayo Clinic to combine extensive, de-identified clinical and claims data to help care providers create the most effective approaches to care

CAMBRIDGE, Mass. & ROCHESTER, Minn.–()–Optum and Mayo Clinic today jointly launched Optum Labs, an open, collaborative research and development facility with a singular goal: improving patient care. Based in Cambridge, Mass., Optum Labs provides an environment where the health care industry can come together to combine information and ideas that benefit patients today while also driving long-term improvements in the delivery and quality of care.

“This will help provide better care to patients, and help the health care industry better define value through outcomes instead of volumes.”

Optum and Mayo Clinic will make their information assets, technologies, knowledge tools and scientific expertise available to organizations interested in pursuing practical new solutions to patient care challenges. As the first and largest integrated, not-for-profit medical group practice in the world, Mayo Clinic will also contribute valuable insights directly from patient experiences. Mayo Clinic’s extensive clinical expertise will be instrumental in guiding Optum Labs’ research agenda and applying research results and insights directly to the patient care environment. Combining Mayo Clinic’s extensive clinical  insights with Optum’s health care claims information will help doctors  better understand all aspects of the patient care experience and refine approaches to care that consistently help patients achieve the best outcomes. Other Optum Labs participants will include academic institutions, life sciences companies, commercial and government payers, and other care providers.

“As a founding partner of Optum Labs, Mayo Clinic is excited to work   with Optum and other organizations to address the challenges and issues facing health care in order to help us provide better care to our  patients, and help lead improvements to the delivery of care,” said John Noseworthy, M.D., president and chief executive officer of Mayo Clinic. “Our strategic research alliance with Optum Labs will leverage what we believe to be the largest combined source of clinical and claims information, providing a more comprehensive picture of patients’ diagnoses, progression of diseases, comparative treatments and outcomes.”

“We are privileged to introduce Optum Labs in partnership with Mayo  Clinic, which has been improving health outcomes for 150 years by continually researching, discovering and doing what’s best for the patient,” said Larry Renfro, chief executive officer of Optum. “Mayo Clinic and Optum are bringing together the best clinical insight, health   information and research expertise to drive innovation that works for care providers and the patients they serve. We also welcome and look   forward to the perspectives, ideas and contributions of future  participants from across the health care system who share the goal of   creating a better future for patient care.”

Making a difference in the lives of patients

With the combined insights of Optum, Mayo and other partners, Optum Labs  will be able to support patient care improvements in many areas, such as:

  •         finding optimal treatments for conditions in a given setting;
  •         understanding variations in care; and
  •         examining the effectiveness of patient care programs and approaches

Using the rich data and other resources of Optum Labs, scientists will  address a broad range of opportunities to improve care for patients.  Examples of the work of Optum Labs scientists include measuring the best treatments for the serious blood cancer chronic myelogenous leukemia (CML), developing applications that measure the relative cost effectiveness of medical devices, analyzing how to improve the diagnosis  of Hepatitis C and increasing the understanding of health disparities among the elderly.

“By combining the Mayo Clinic’s robust clinical insight with Optum’s extensive claims information, we will be able to better understand health care delivery over time, compare the effectiveness of care we  provide today, and analyze the total cost of care for specific  procedures or diseases,” said Veronique Roger, M.D., M.P.H., director of  the Mayo Clinic Center for the Science of Health Care Delivery. “This will help provide better care to patients, and help the health care industry better define value through outcomes instead of volumes.”

“Bringing together in one location health information and insights from  many contributors can provide a deeper understanding of important trends  and patient care issues that no single organization could achieve on its  own,” said Andy Slavitt, group executive vice president of Optum. “At Optum Labs, we have the opportunity to generate insights and develop  practical innovations that care providers, life sciences companies and government agencies can begin using today to improve patient care.”

About Mayo Clinic Mayo  Clinic is a nonprofit worldwide leader in medical care, research and  education for people from all walks of life. The organization focuses a team of experts on one patient at a time, as it has for nearly 150  years. Its proven model of care makes Mayo Clinic a trusted leader in advancing medicine and solving complex problems.

About Optum Optum (    is a leading information and technology-enabled health services business  dedicated to helping make the health system work better for everyone. Optum comprises three companies – OptumHealth, OptumInsight and OptumRx   – representing over 35,000 employees worldwide who collaborate to deliver integrated, intelligent solutions that work to modernize the  health system and improve overall population health.


Mayo Clinic Karl Oestreich, 507-284-5005 or Optum Jeffrey Smith, 773-907-0860

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Posted by on Jan 28, 2013 in Medical Research Data | 0 comments

Databases offering online access to medical evidence

Cochrane Collection

Databases offering online access to medical evidence

Agency for Healthcare Research and Quality (AHRQ) at the U.S. Department of Health & Human Services : summaries of evidence, clinical guidelines and more; free

ARIF Reviews Database from the Aggressive Research Intelligence Facility at the University of Birmingham, UK : systematic reviews; free

Best Health from the BMJ Evidence Centre : information for patients; fee-based

Best Practice from the BMJ Evidence Centre : clinical assessment tool for practitioners; fee-based

Clinical Evidence from the BMJ Evidence Centre : summaries of evidence; for medical professionals; fee-based

Clinical Knowledge Summaries (from NHS Evidence) : evidence summaries; downloadable leaflets for patients, podcasts; for medical professionals ; free

The Cochrane Library from The Cochrane Collaboration : systematic reviews; fee-based or free online access through funded provisions

Database of Abstracts of Reviews of Effects (DARE) from the Centre for Reviews and Dissemination (UK) : synopses of syntheses of evidence; free

DynaMed from Ebsco : summaries of evidence; for medical professionals; fee-based

EBM Guidelines from Wiley : practice guidelines and evidence summaries; for medical professionals, fee-based

Effective Older People Care (beta) from the Cochrane Health Care for Older Peoples Field : a gateway to Cochrane evidence and more for the management of older people’s care and rehabilitation; free with registration

Epistemonikos managed by members of the Evidence-Based Medicine Unit, Pontificia Universidad Católica de Chile and other collaborators is “a multilingual, collaborative and free database of health evidence”; free.

Essential Evidence Plus from Wiley : “a powerful resource packed with content, tools, calculators and alerts for clinicians who deliver first-contact care”; fee-based

Evidence Updates (formerly BMJ Updates) from the BMJ Evidence Centre : systematic reviews; PLUS ratings used to help select content; free with registration

Harrison’s Practice: answers on demand from McGraw-Hill : “Point-of-Care Diagnosis and Treatment Information – Delivered to Your Desktop or Mobile Device” : online registry of systematic reviews on the effectiveness of public health and health promotion interventions; free with registration

Health Systems Evidence from McMaster Health Forum and partners : “a repository of syntheses of research evidence about governance, financial and delivery arrangements within health systems, and about implementation strategies that can support change in health systems”; free

HEED: Health Economic Evaluations Database from Wiley : economic evaluations and comparative analysis of medicines and interventions; fee-based; free for Cochrane contributors

JAMAevidence Using Evidence to Improve Care from McGraw-Hill : portal to evidence summaries and decision-making tools; for medical professionals; fee-based

National Guidelines Clearinghouse from the US Dept of Health & Human Services : clinical practice guidelines; free

NHS Evidence from the National Institute for Health and Clinical Excellence (NICE) : meta-search portal for evidence, guidance and government policy data; for medical professionals; free

NHS Evidence – QIPP : a collection of quality and productivity case studies and evidence summaries organised around topic areas; for medical professionals; free

NHS Evidence Specialist Collections : evidence summaries organised by medical conditions, topics and health populations; free

nursing+ Best Evidence for Nursing Care from McMaster University’s Health Information Research Unit : systematic reviews; PLUS ratings used to help select content; free with registration

OBESITY+ Online best evidence service in tackling obesity from McMaster University’s Health Information Research Unit : systematic reviews; PLUS ratings used to help select content; free with registration

OTseeker (Occupational Therapy Systematic Evaluation of Evidence) : systematic reviews and RCTs; free

PDQ-Evidence for Informed Health Policymaking provides access to systematic reviews of health systems evidence; put together by a team including members of the Epistemonikos Project, the Norwegian Knowledge Centre for the Health Services and Cochrane Effective Practice and Organisation of Care (EPOC); free

PEDro Physiotherapy Evidence Database from the Centre of Evidence-Based Physiotherapy (CEBP) : trials, reviews and guidelines; for medical professionals; free

Physiotherapy Choices from the Centre of Evidence-Based Physiotherapy (CEBP) : trials, reviews and guidelines; for patients; free

PIER: The Physicians’ Information and Education Resource from the American College of Physicians : summaries of evidence; PLUS ratings used to help select content; for ACP members only

PubMed Clinical Queries : evidence-based searching in Medline; free

Rehab+ from McMaster University’s Health Information Research Unit : systematic reviews; PLUS ratings used to help select content; free with registration

Special Collections from The Cochrane Library from Wiley : thematic collections of evidence on topics such as tobacco addition, breast cancer, and more; free

Therapeutics Initiative (TI) Evidence-Based Drug Therapy from The University of British Columbia : drug assessments and therapeutics newsletters; for medical professionals; free with registration

Trip Database : clinical meta-search tool; for medical professionals; free

UpToDate from Wolters Kluwer Health : summaries of evidence; for medical professionals; fee-based


For a useful overview of medical evidence portals online, see also: Where’s the best evidence? Free and fee-based medical evidence on the web (2010) by Dean Giustini, UBC Biomedical Branch Librarian

Cochrane Collaboration (2013). Databases offering online access to medical evidence.  Retrieved January 27, 2013 from

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Posted by on Sep 15, 2010 in Medical Research Data | 0 comments

Global Medical Research – Helpful Databases

Global Medical Research – Helpful Databases

Listing of Open Databases for Medical Research

Alzheimer’s Database

Bioinformatics Resource for Oral Pathogens
BioMart: developed jointly by the Ontario Institute for Cancer Research (OiCR) and the European Bioinformatics Institute (EBI).
Bioinformatic Harvester: 4DXp
UCSC GenomeBrowser
WikipediaWikiProtein Harvester Sequence Search device –
YaCy-Sciencenet p2p search engine


Cancer Clinical Trials Database: National Cancer Institute
Cancer Genome Atlas Data Portal
Cancer Molecular Analysis Portal: Cancer Biomedical Informatics Grid Cancer: PDQ Natinal Cancer Institute Comprehensive Cancer Database
Carcinogenic Potency Database
Cell Signalling Information
Comprehensive Microbial Resource
Collaborative Bio Curation
CRISP (Computer Retrieval of Information on Scientific Projects) is a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other research institutions
Cytokines & Cells Online Pathfinder
Citeline- Worldwide drug development activity


Diabetes Association Researcher Database
Diseases Database
Diseases and Disorders Database: Karolinkska Institutet – Sweden


Entrez: Life Sciences Search Engine
ennfsa Environmental Health and Toxicology

Genetic Association Database General Practice Notebook: Database of clinical medicine (United Kingdom) Genomic Variants (Database)

Health on the Net Database
HIV Molecular Immunology
Human Gene Database Database Download

Indian Bioresource Information Network
International Classification of Diseases Database
International Protein Index Intute: Health and Life Sciences

Japan Biological Information Research Center
Journal Watch

Medical Images: Karolinkska Institutet, Sweden Medical Journal Library Databases: Washington University in St. Louis School of Medicine
Medline Plus
Medical Subject Headings Browser
Mediscan Image Data Search
Merck Disease Modules Multilingual Glossary of Medical Terms in 9 European Languages

National Cancer Institute 3D Structure Database
National Center for Biotechnology Information
National Library of Medicine Catalog
National Library of Medicine Databases and Resources
National Library of Medicine Locator Plus
National Library of Medicine Gateway
NCBI Resource Guide NCI Screening Data Miner: A tool for interactive analysis and visualization of the National Cancer Institute anti-tumor datasets. Contains 41,000 chemical compounds versus 155 cancer cell lines.
Neuromuscular Disease Center
New Medicine Oncology Database
National Institute of Diabetes and Digestive and Kidney Diseases Resources

Panther: Classification of Genes and Proteins
Parasites:  American Society of Tropical Medicine and Hygene
Proteome Commons

Rare Disease Database

Science Links Japan
Signaling Gateway, powered by the San Diego Supercomputer Center
Stanford Online Universal Resource for Clones and ESTs

tRNA Database

UCSC Gene Sorter USDA Plants Database

Visualizing Splices of Genes from EST Data

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Posted by on Sep 15, 2010 in Medical Research Data | 0 comments

Medical Research Feeds

Medical Research Feeds

Centers for Disease Control and Prevention

Case Studies in Environmental Medicine

CDC Emergency Preparedness and Response

CDC Flu Updates

CDC HIV/AIDS Prevention

CDC Public Health Law News

CDC Travel News Emerging Infectious Disease Journal

Health Information for International Travel

CDC Morbidity and Mortality Weekly Report

CDC Preventing Chronic Disease

Vital Stats

Condition News Feeds

Alzheimer Forum News

General Medical News Sources

US News & World Report Health Archive

BBC: Health Website

CBS: Health News Newsweek: Health News

CBC:Canada Health News World

Reuters Health and Science

Global Health (HIV, malaria, TB news)

World (Healthcare leadership))

Medicine SciBX – Science Business Exchange

Nature Medicine

Genetic Engineering & Biotechnology News

Global News

Reuters Alert Net: Alerting humanitarian agencies to world events

Health Map: Global Disease Alert Map (ProMed)

Global Latest News

World Health Assembly

Harvard World Health News

European Science Foundation

National Institutes of Health News Feeds

National Institutes of Health Event Calendar

World Health Organization – WHO

WHO – World Health Organization News Feeds WHO – World Disease Outbreak News Feeds


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Posted by on Sep 15, 2010 in Medical Research Data | 0 comments

Guidelines on Clinical Trials

Guidelines on Clinical Trials

A Standard for the Scientific and Ethical Review of Trials (ASSERT) Australian Therapeutic Goods Administration Association of Clinical Research Professionals

CancerIndex Central Committee on Research Involving Human Subjects (CCMO) Clinical Trials Tool Kit The Cochrane Collaboration Community of Science The CONSORT Statement

European Agency for the Evaluation of Medicinal Products (EMEA) European Clinical Trials Directive 2001/20/EC

Heads of EU Agencies Website

International Committee of Medical Journal Editors (ICMJE) – Uniform Requirements for Manuscripts Submitted to Biomedical Journals
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals
for Human Use – Guideline for Good Clinical Practice (ICH GCP)
International Directory of Government and Regulatory Bodies (Pharmweb)

James Lind Library

Medical Dictionary for Regulatory Activities Terminology (MedDRA)

PhRMA New Medicines in Development Database

The Quality Of Reporting Of Meta-analyses (QUOROM) Statement

The UK Medicines and Healthcare products Regulatory Agency (MHRA)
UK Central Office for Research Ethics Committees (COREC)
UK Department of Health Policy and Guidance on Research and Development
UK National Library for Health
US Food and Drug Administration (FDA)
US National Institutes of Health (NIH): Institutes, Centers & Offices
US Office for Human Research Protections (OHRP)

WHO Guidelines for Good Clinical Practice for Trials on Pharmaceutical Products
WHO International Clinical Trials Registry Platform (ICTRP) WHO operational guidelines for ethics committees that review biomedical research
World Medical Association Declaration of Helsinki

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