Global Medical Research Member BiosCurrently Global Medical Research.org has 122 active members who are medical researchers or computer scientists. Members of Global Medical Research are welcome to share their bio information in order to encourage collaboration. Please email diane@globalmedicalresearch.org, if you would like to include your bio.
Thomas W. Bruice, M.D., Ph.D. Summary:
Over thirty years of experience in basic, applied and translational research on binding and catalysis of nucleic acids, proteins and small molecules, including: chemistry; bioconjugate and modification chemistry; pharmaceutical and medicinal chemistry; radiochemical synthesis; chemo-enzymatic synthesis; amino acid, peptide, protein, nucleotide, oligonucleotide, nucleic acid and small molecule design, engineering and bioorganic chemistry; biochemistry-biophysics; molecular biology; chemical biology; mechanistic enzymology; isotopic probes and effects methodologies; molecular recognition and structure-based design; novel assay design, development, implementation and management; database and information technology implementation and management; novel drug discovery for regulation of gene expression at the DNA replication, mRNA transcription, protein translation and protein function levels; clinical laboratory and diagnostic medicine; molecular pathology; and translational medicine.
Education:
B.A., Chemistry and Biochemistry, with Honors, Revelle College, U.C.S.D., 1970-1974; Ph.D., Biochemistry-Biophysics and Pharmaceutical Chemistry, U.C.S.F. Medical Center, 1974-1980; NIH National Research Service Award Post-Doctoral Fellow, Chemistry and Biochemistry, Harvard University, 1980-1982; M.D., Ph.D.-to-M.D. Program, University of Miami School of Medicine, 1982-1984; Clinical Resident and Medical Research Fellow, Clinical Pathology/Laboratory Medicine, U.C.L.A. School of Medicine, 1984-1987; Licensed Physician, California, 1987-present; California Institute for Cancer Research Fellow, Chemical Biology and Molecular Biology, U.C.L.A., 1987-1990. Scientific Contributions:
An established track record of demonstrated, diverse accomplishments, broadly published in leading peer-reviewed journals, with numerous issued and pending patent applications, and invited and application accepted participation in national and international scientific forums. Contributions made to a broad range of basic, applied and translational research, molecular toolkit, diagnostic and drug discovery modalities, including: laboratory medicine-based clinical research on diabetes and enforced bedrest as a surrogate model for prolonged weightlessness for the NASA Space Station Program; structural protein chemistry of mitochondrial electron transport proteins (cytochromes); novel protein modification chemistry technology; mechanism-based enzyme inhibition by nucleotide analog anti-cancer drugs; seminal determination of the complete energetics of an enzyme-catalyzed reaction; engineered alternative and association-induced enzyme substrates for biotechnology and drug discovery; elucidation of reduction of mitochondrial oxidative stress as an etiologic molecular mechanism of life extension by caloric restriction; semi-synthetic DNAse restriction enzymes; folded RNA mimetic decoy oligonucleotides; stabilization of folded RNA mimetic decoy oligonucleotides secondary structure by cross-linking and covalent H-bond mimicry; selection of aptamer oligonucleotides; anti-sense (AS) oligonucleotides core technology; unambiguous, unbiased and complexity independent, isothermal combinatorial chemistry affinity-based screening strategies and application to selection and optimization for hybridization to target mRNA of AS oligonucleotides; competitive, cooperative and allosteric binding to RNA structural elements—seminal “riboswitches”; small molecule bis-metal-chelate RNA hydrolases; proteomics determination of antigenic determinants for infectious disease diagnostics; anti-genomic DNA and anti-dsRNA groove binding small molecule gene expression regulators and counter-biowarfare agents and their identification via inventive isothermal high-throughput screening assays; cooperative binding allosteric gene switch technology; anti-gene oligonucleotides (DNAi); and medicinal chemistry structure-activity relationship (SAR)-driven nucleoside phosphate mimics enzyme inhibitors of nucleotide binding proteins and prodrugs thereof. An active member of numerous professional societies, reviewer for select journals and recipient of several awards. Contact Information:
Thomas W. Bruice, M.D., Ph.D.
Co-Founder & Vice President, Preclinical Research at Carlsbad Pharmaceuticals, Inc.
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Chung-Chu Chen
Summary:
Chung-Chu Chen received the B.Sc. degree in mechanical engineering from National Taiwan University, Taiwan, in 1994 and the Ph.D. degree in power mechanical engineering from National Tsing Hua University, Taiwan in 1999. He worked at Microsystem Technology Division, ERSO/ITRI, Taiwan, between 2000 and 2002. He held a post doctoral position at Stanford University between 2002 and 2004. He was a visiting researcher in SSIM program at Wayne State University between 2004 and 2006. He worked at Medical Electronics and Device Technology Center, ITRI, Taiwan between 2006 and 2008. He is currently working on a medical device fellowship at Center for Research in Cardiovascular Interventions, Stanford University. His research interests are microfluidic device design, simulation, fabrication and characterization including bio-sensing, cell culturing, cell sorting, micro droplet dispensing as well as other medical applications and he holds 15 related patents.
Specialties:
Design & Simulation: CFD-ACE+ / L-Edit / CoventorWare / MEMSPro / ANSYS / StarCD / AutoCAD / SolidWorks / Goldfire Innovator MEMS: LPCVD / RIE / Plasma Etching / Wet Etching / PECVD / Photolithography / E-beam Evaporator / RF Sputter / Electroplating / Anodic Bonding / Micro Screen Print Characterization & Imaging: SEM / AFM / Optical transmission and reflection spectrometry / Raman spectrometry Optical Laboratory: LDV / Thermal Liquid Crystal Imaging / PIV / High Speed Stroboscope
Contact Information:
Stanford-Taiwan Biomedical Fellowship Program
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Olena Palyvoda, Ph.D.
Summary
Expertise in cell imaging, cell-surface biochemistry, surface science, self-assembly, micro- and
nanotechnology and development of advanced micro-systems for bio-medical research
Research in neural interfaces to implantable microelectronic devices for neuronal lesion recovery and
molecular engineering approaches for nanoscience application in genotoxicity
Screening methods for exposure assessment of human population to
genotoxic substances and estimation individual radiosensitivity in cancer patients
Cell signalling and regulation of cell growth and metabolism in normal and cancer cells Education
Laboratory of Signals Transduction, Institute of Experimental Biology, Warszaw Post.Doc., 2003 - 2003
Nucleic Acids Laboratory, Department of Molecular Biology, Center of Oncology Post.Doc., Molecular Biology, 2003 - 2003
Center of Oncology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland
PhD, Medical Sciences, 1988 - 2002
Specialties
Strong background in cell culturing techniques
SDS-PAGE
Immunoassays
Fluorescent microscopy
Live Cell imaging
Raman spectroscopy
Fourier transform infrared spectroscopy techniques
with additional skills in thin film and device characterization techniques (SEM (Hitachi-S 2400),
Atomic Force Microscopy, Ultraviolet/Visible/Near Infrared Spectroscopy (UV/Vis/NIR)
Experience in plasma etching, optical lithography in 100 class clean room environment
Activities and Societies:
Member of European Association for Cancer Research (EACR),
Member of Federation of European Biochemical Societies (FEBS),
Member of Shevchenko Scientific Society,
Member of Ukrainian Biochemical Society,
Board member of Ukrainian-American Chamber of Commerce,
Board member of Ukrainian Selfreliance Michigan Federal Credit Union,
Board member of the Michigan Friends of the Ukrainian Catholic University
Contact Information:
Olena Palyvoda, Ph.D
Assistant Professor-Research, Wayne State University
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Vadim Paluy, MD
Vadim has formal training as a Board Certified Internist with clinical practice and research experience in Russia and the US. Dr. Paluy has over 15 years of clinical research experience including all aspects of project management as well as audit and monitoring clinical trials, investigator/patient recruitment, protocol and CRF development, SOP writing, and development of study specific educational materials. Dr. Paluy has had considerable research interests in multiple therapeutic areas including oncology, infectious diseases, autoimmune disorders, psychiatry and neurology among others. In November 1992 Dr. Paluy founded Placet Research that currently offers consulting services to medical device, pharmaceutical, and biotechnology companies internationally in the capacity of audit, project management and monitoring. He has very extensive experience working with different types of organizations such as academic institutions (Stanford University), sponsor companies (Merck, Genentech, J&J, BMS, Daiichi, PDL, Telik, Ilypsa, etc) and CROs (ICON, Advanced Biologics, PPD, CSMG, i3Statprobe, Covance, Kendle, Quintiles, MDS, etc). Dr. Paluy is a frequent guest speaker at conferences and seminars as well as a consultant to Clinical Advisors, an exclusive community of academic and industry professionals who provide consulting services to the financial industry. In 2004 he was one of co-founders of BIORAMA (Biological Russian-American Association) and he was a guest speaker at the Optimizing Patient Enrollment in Clinical Trials Forum (International vs. USA-based)
Contact Information:
Vadim Paluy, MD
Principal Clinical Research Consultant/Auditor
Placet Research Global Services
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